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Filtered Search Results
Medchemexpress LLC Cinchonidine (α-Quinidine) | 485-71-2 | 99.6% | 294.39 | 25 G
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Cinchonidine is a cinchona alkaloid found in plants such as *Cinchona officinalis*. It serves as a building block in asymmetric synthesis and exhibits antimalarial activities.
- Acts as a weak inhibitor of the serotonin transporter (SERT)
- Used as a building block in asymmetric synthesis
- Exhibits antimalarial activities
- Available in solid, white to off-white appearance
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Aobchem AOBCHEM
5000865241 2 3-DIMETHOXY-6-FLUOROPHENYLBO
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Apexbio Technology LLC Zonisamide sodium 68291-98-5 200mg
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Zonisamide sodium (CAS 68291-98-5) is a synthetic 1 2-benzisoxazole derivative that was the first of its class developed for seizure modulation It exerts anticonvulsant activity primarily by blocking voltage-gated sodium channels and inhibiting T-type calcium channels thereby stabilizing neuronal membranes and reducing repetitive neuronal firing In biomedical research Zonisamide sodium is utilized for elucidating neuronal excitability investigating epilepsy pathophysiology and evaluating potential antiepileptic therapies in in vitro and in vivo models
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000427390 CINCHONIDINE 5G
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Medchemexpress LLC MEDCHEMEXPRESS LLC
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5000712325 GLYCOCHENODEOXYCHOLI 200MG
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Apexbio Technology LLC Domperidone 57808-66-9 200mg
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Domperidone is a small-molecule antagonist targeting the dopamine D2 receptor It is designed to inhibit peripheral dopamine receptors thereby enhancing gastrointestinal motility and accelerating gastric emptying Domperidone exerts its biological activity primarily through peripheral D2 receptor antagonism Based on these pharmacological properties domperidone holds research potential in the investigation and management of gastroparesis and as a comparative compound for mechanistic studies of gastric motility disorders
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Apexbio Technology LLC Coenzyme Q10 303-98-0 200mg
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Coenzyme Q10 (CAS 303-98-0) is a lipophilic benzoquinone involved in mitochondrial electron transport and cellular energy production It functions as an essential electron carrier within the electron transport chain facilitating ATP synthesis and exhibiting antioxidant properties by mitigating oxidative damage Coenzyme Q10 is frequently studied for its role in cellular metabolism bioenergetics and redox homeostasis Due to its involvement in mitochondrial function it is widely applied in research on metabolic disorders neurodegeneration and cardiovascular diseases The compound is soluble in organic solvents such as chloroform benzene and carbon tetrachloride For optimal stability it should be stored sealed in cool and dry conditions
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Apexbio Technology LLC AM-095 free base 1228690-36-5 200mg
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AM-095 free base (CAS 1228690-36-5) is an orally bioavailable antagonist of lysophosphatidic acid receptor 1 (LPA1) It demonstrates inhibitory activity against recombinant human and mouse LPA1 with IC50 values of 0 98 M and 0 73 M respectively In vitro AM-095 suppresses LPA1-mediated chemotaxis in both mouse LPA1/CHO cells (IC50 0 78 M) and human A2058 melanoma cells (IC50 0 23 M) In murine models it blocks LPA-induced histamine release and reduces collagen and protein levels in bronchoalveolar lavage fluid with ED50 values of 8 3 mg/kg and 10 mg/kg respectively Additionally AM-095 decreases macrophage and lymphocyte infiltration in bleomycin-induced lung injury models supporting its utility in studies of LPA1-mediated fibrotic and inflammatory processes
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eMolecules 4965-36-0 | 7-Bromoquinoline | Chem-Impex | MFCD03695823 | 208.058 | C9H6BrN | 95.000 | Brc1ccc2cccnc2c1 | 5g | 386900399
7-Bromoquinoline | Chem-Impex | 4965-36-0 | MFCD03695823 | 208.058 | C9H6BrN | 95.000 | Brc1ccc2cccnc2c1 | 5g | 386900399
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Medchemexpress LLC RU-521 | 2262452-06-0 | 100.0% | 415.23 | 50 MG
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RU.521 is a potent and selective cyclic GMP-AMP synthase (cGAS) inhibitor. It inhibits cGAS-mediated interferon upregulation and suppresses dsDNA-activated reporter activity.
- Inhibits cGAS-mediated interferon upregulation.
- Suppresses dsDNA-activated reporter activity with an IC50 of 0.7 μM.
- Reduces constitutive expression of interferon in macrophages from a mouse model of Aicardi-Goutières syndrome (AGS).
- Reduces symptoms from sepsis in mice, increasing cardiac function and decreasing inflammatory responses.
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eMolecules 1138331-79-9 | 1-(Cyclopropyloxy)-3,5-difluorobenzene | Synthonix - Stock | MFCD16996191 | 170.159 | C9H8F2O | 95.000 | Fc1cc(F)cc(OC2CC2)c1 | 1g | 495875274
1-(Cyclopropyloxy)-3,5-difluorobenzene | Synthonix - Stock | 1138331-79-9 | MFCD16996191 | 170.159 | C9H8F2O | 95.000 | Fc1cc(F)cc(OC2CC2)c1 | 1g | 495875274
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Apexbio Technology LLC AZ5104 1421373-98-9 200mg
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AZ5104 (CAS 1421373-98-9) is a demethylated metabolite of AZD9291 functioning as a potent inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase It exhibits high affinity for mutant EGFR forms with IC50 values below 1 nM for EGFR L858R/T790M 6 nM for EGFR L858R 1 nM for EGFR L861Q and 25 nM for wild-type EGFR Compared to AZD9291 AZ5104 demonstrates increased potency in cellular models harboring EGFR ex19del (PC-9) T790M (H1975) and wild-type EGFR (LOVO) In vivo oral administration in mice led to a plasma metabolite level of 33% at 3 hours post-dose and 5 mg/kg/day reduced tumor growth in relevant models AZ5104 serves as a valuable tool for studying EGFR-driven cancer mechanisms and resistance
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Ambeed AMBEED
5000868456 1-QUINOLIN-2-YLETHANONE 1GR
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Medchemexpress LLC Sitravatinib | 1123837-84-2 | 99.6% | 629.68 | 200 MG
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Sitravatinib (MGCD516) is an orally bioavailable receptor tyrosine kinase (RTK) inhibitor that demonstrates potent single-agent antitumor efficacy. It enhances the activity of PD-1 blockade by promoting an antitumor immune microenvironment, making it suitable for various research applications in oncology.
- Orally bioavailable receptor tyrosine kinase (RTK) inhibitor
- Potent single-agent antitumor efficacy
- Enhances PD-1 blockade activity
- Promotes an antitumor immune microenvironment
- Soluble in DMSO for in vitro studies
- Available in solid form for various research needs
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![Apexbio Technology LLC prostate apoptosis response protein PAR-4 (2-7) [Homo sapiens] 25mg](https://assets.fishersci.com/TFS-Assets/CCG/product-images/5000097078.png-250.jpg)
Apexbio Technology LLC prostate apoptosis response protein PAR-4 (2-7) [Homo sapiens] 25mg
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Prostate apoptosis response protein PAR-4 2-7 is a short peptide targeting transcriptional regulation pathways It is designed to modulate transcription factor activity thereby influencing apoptosis mechanisms particularly in prostate cells PAR-4 2-7 exerts its biological activity primarily through interaction with transcription factors via a leucine zipper zinc finger domain facilitating apoptosis in transformed or malignant cells while sparing normal cells Based on these properties PAR-4 2-7 holds research potential in studies investigating tumor suppression mechanisms and transcription-mediated apoptosis regulation in oncology and therapeutic research
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